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Ampyra Drug Interactions

Studies have shown that Ampyra is unlikely to react with other medications because it is not significantly metabolized by the liver (it is excreted from the body basically unchanged). However, although no drug interactions with Ampyra have been identified at this time, it does not mean that no interactions exist; there still may be interactions that have not yet been discovered.

Does Ampyra Interact With Other Drugs?

Ampyra™ (dalfampridine) is a prescription medication licensed to improve walking in people with multiple sclerosis (MS). It is a potassium channel blocker. At this time, no drug interactions with Ampyra have been identified.
Studies have shown that most of a dose of Ampyra is excreted through the urine unchanged. This means that the medication travels through the body and is removed from the body (by the kidneys through the urine), mostly without being metabolized (broken down) by the liver. Because it is not metabolized significantly, it is unlikely to be affected by other drugs that would affect liver metabolism (this is a major way that many drugs interact).
It should be noted that Ampyra should not be taken with compounded 4-aminopyridine or fampridine, as such medications contain the same active ingredient as Ampyra (4-aminopyridine and fampridine are other names for dalfampridine, the active ingredient in Ampyra).

Final Thoughts on Drug Interactions With Ampyra

In clinical studies of Ampyra, no drug interactions have been identified. However, this does not necessarily imply that there really are no drug interactions with Ampyra. This medication has not been studied with every possible drug, and there may be drug interactions that are discovered at a later date. However, at this time Ampyra seems unlikely to cause drug interactions.
Nonetheless, it is always a good idea to give your healthcare provider a complete list of all medications you are taking, including prescription drugs, nonprescription drugs, and herbs and supplements.
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Ampyra Medication Information

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