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Ampyra Warnings and Precautions

Before taking Ampyra, make sure to tell your healthcare provider if you have kidney disease or have ever had a seizure. This medication is not suitable for everyone, so it is important to understand the potential risks. Warnings and precautions for Ampyra also extend to people with certain allergies and women who are pregnant or breastfeeding.

What Should I Tell My Healthcare Provider Before Taking Ampyra?

You should talk with your healthcare provider prior to taking Ampyra™ (dalfampridine) if you have:
  • Ever had a seizure
  • Kidney disease, such as kidney failure (renal failure)
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings for Ampyra

Some warnings and precautions to be aware of prior to taking Ampyra include the following:
  • Ampyra may increase the risk of seizures. If you have ever had a seizure (for any reason), you should not take this medication. If you have a seizure while taking Ampyra, you should stop taking the medication (and should never start taking it again).


  • Most seizures with this medication have occurred in the first few days or weeks when the drug is first started, and most cases have been reported in people who have never had a seizure before. Taking a higher-than-normal dosage greatly increases the risk of seizures. 


  • The kidneys remove Ampyra from the body. If your kidneys are not functioning properly, this drug may build up in the bloodstream, increasing your risk of seizures. People with moderate or severe kidney impairment should not take this medicine. At this time, it is not known how Ampyra may affect people with only mild kidney impairment, although it is predicted that the risk of seizures may be increased.
  • The generic name for Ampyra is dalfampridine, sometimes known as 4-aminopyridine (4-AP) or fampridine. Do not take Ampyra with other 4-aminopyridine or fampridine medications. There are no other 4-aminopyridine or fampridine medications approved by the FDA (other than Ampyra), although such medications may be available through compounding pharmacies.
  • Ampyra is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known (see Ampyra and Pregnancy).
  • It is unknown if Ampyra passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to taking the drug (see Ampyra and Breastfeeding).
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Ampyra Medication Information

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