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Baclofen Drug Interactions
Among the medications that may cause drug interactions with baclofen are antidepressants, antipsychotics, and sleep medications. When baclofen is combined with any medication that results in drowsiness or sedation, it may increase the risk of side effects, such as severe drowsiness, confusion, or dizziness. Before using baclofen, talk with healthcare provider about any interactions that may apply to you.
Baclofen (Lioresal®, Gablofen®) can potentially interact with a number of other medications. Some of the medicines that may lead to drug interactions with baclofen include but are not limited to:
- Alcoholic beverages (or other products that contain alcohol)
- Antidepressant medications
- Antihistamines (including many nonprescription cold, cough, allergy, motion sickness, and sleep medications)
- Antipsychotics, such as:
- Aripiprazole (Abilify®)
- Asenapine (Saphris®)
- Chlorpromazine (Thorazine®)
- Clozapine (Clozaril®, FazaClo®)
- Fluphenazine (Prolixin®)
- Haloperidol (Haldol®)
- Iloperidone (Fanapt®)
- Loxapine (Loxitane®)
- Lurasidone (Latuda®)
- Molindone (Moban®)
- Olanzapine (Zyprexa®, Symbyax®)
- Paliperidone (Invega®)
- Perphenazine (Trilafon®)
- Pimozide (Orap®)
- Prochlorperazine (Compazine®, Compro®)
- Quetiapine (Seroquel®)
- Risperidone (Risperdal®)
- Thioridazine (Mellaril®)
- Thiothixene (Navane®)
- Trifluoperazine (Stelazine®)
- Ziprasidone (Geodon®)
- Barbiturates, such as:
- Amobarbital (Amytal®)
- Butalbital (Fioricet®, Fiorinal®)
- Pentobarbital (Nembutal®)
- Phenobarbital (Luminal®)
- Secobarbital (Seconal®)
- Benzodiazepine sedatives, such as:
- Alprazolam (Xanax®, Xanax XR®)
- Chlordiazepoxide (Librium®, Limbitrol®, Librax®)
- Clonazepam (Klonopin®)
- Clorazepate (Tranxene®)
- Diazepam (Valium®)
- Estazolam (ProSom®)
- Flurazepam (Dalmane®)
- Lorazepam (Ativan®)
- Midazolam (Versed®)
- Temazepam (Restoril®)
- Triazolam (Halcion®)
- Muscle relaxants, such as:
- Carisoprodol (Soma®)
- Chlorzoxazone
- Cyclobenzaprine (Flexeril®, Amrix®)
- Dantrolene (Dantrium®)
- Metaxalone (Skelaxin®)
- Monoamine oxidase inhibitors (MAOIs), such as:
- Isocarboxazid (Marplan®)
- Phenelzine (Nardil®)
- Rasagiline (Azilect®)
- Selegiline (Eldepryl®, Emsam®, Zelapar®)
- Tranylcypromine (Parnate®)
- Narcotics or opiates, such as hydrocodone/APAP (Lortab®, Vicodin®, and many others) or oxycodone (OxyIR®, OxyContin®)
- Sleep medications.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD