Multiple Sclerosis Channel
Topics & Medications
Related Channels

Baclofen Drug Interactions

Among the medications that may cause drug interactions with baclofen are antidepressants, antipsychotics, and sleep medications. When baclofen is combined with any medication that results in drowsiness or sedation, it may increase the risk of side effects, such as severe drowsiness, confusion, or dizziness. Before using baclofen, talk with healthcare provider about any interactions that may apply to you.

Baclofen Interactions: An Overview

Baclofen (Lioresal®, Gablofen®) can potentially interact with a number of other medications. Some of the medicines that may lead to drug interactions with baclofen include but are not limited to:
  • Alcoholic beverages (or other products that contain alcohol)



  • Antihistamines (including many nonprescription cold, cough, allergy, motion sickness, and sleep medications)


  • Barbiturates, such as:
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
  • Benzodiazepine sedatives, such as:
  • Muscle relaxants, such as:
  • Monoamine oxidase inhibitors (MAOIs), such as:


  • Sleep medications.
Ways to Prep Your Kitchen to Eat Well During Cancer Treatment

Baclofen Medication Information

Referring Pages:
Terms of Use
Advertise with Us
Contact Us
About eMedTV
Privacy Policy
Copyright © 2006-2019 Clinaero, Inc.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.