A healthcare provider may prescribe baclofen (Lioresal®, Gablofen®) to treat spasticity. Specifically, baclofen oral tablets are approved to treat spasticity due to multiple sclerosis (MS) or spinal cord injury or disease. An injectable form, which delivers the medication directly to the spinal cord using a pump, is approved to treat severe spasticity due to various causes, including MS, spinal cord injury or disease, or cerebral palsy.
It is not fully understood exactly how baclofen oral tablets work to treat spasticity. This medication is chemically similar to gamma-aminobutyric acid (GABA), a chemical messenger in the central nervous system. The primary activity of GABA is to inhibit nerve signals, and baclofen might have actions that are similar to GABA.
The baclofen oral tablets come in two strengths (10 mg and 20 mg) and are typically taken three or four times a day. The tablets are only available in generic form (the brand-name version is no longer manufactured). Possible side effects may include drowsiness, dizziness, and weakness.
(Click Baclofen for more information on how baclofen oral tablets can help treat spasticity caused by several conditions related to brain or spinal cord damage. This article also discusses general dosing guidelines, safety precautions, and tips to ensure a safe, effective treatment process.)