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Dantrium Dosage

Dosing Guidelines for Malignant Hyperthermia

Dantrium may be used to prevent or treat malignant hyperthermia. The medication may also be used after malignant hyperthermia has occurred to prevent symptoms from recurring.
 

Dose of Dantrium to Prevent Malignant Hyperthermia

The usual recommended dose of oral Dantrium (Dantrium capsules) to prevent malignant hyperthermia is 4 to 8 mg per kg per day (about 1.82 to 3.64 mg per lb per day) divided into three or four smaller doses per day. This amount is normally given starting one to two days before surgery, with the final dose given three to four hours before surgery.
 
The usual recommended dose of Dantrium injection to prevent malignant hyperthermia is 2.5 mg per kg (about 1.14 mg per lb) given slowly into a vein over about an hour (this is called an IV infusion). The dose is normally started about 75 minutes before surgery. Additional doses may be needed during surgery if signs of malignant hyperthermia develop. If necessary, your healthcare provider will determine the amount you need during surgery.
 

Dantrium Dosage to Treat Malignant Hyperthermia

The usual recommended dose of Dantrium injection to treat an episode of malignant hyperthermia is an initial dose of at least 1 mg per kg body weight (0.45 mg per lb) given as a rapid injection into a vein (this is called an IV push). Additional doses will be given until symptoms have subsided or a total of 10 mg per kg (4.54 mg per lb) has been given.
 

Post-Malignant Hyperthermia Follow-up Treatment

The usual recommended dose of oral Dantrium (Dantrium capsules) after an episode of malignant hyperthermia and to prevent a recurrence is 4 to 8 mg per kg per day (about 1.82 to 3.64 mg per lb per day), divided into four smaller doses per day. This dose is normally given for one to three days.
 
If oral Dantrium cannot be used, the medicine may be given as an injection. The minimum dose in this case is normally 1 mg per kg (about 0.45 mg per lb); however, doses are highly individualized and can vary from person to person.
 
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Dantrium Medication Information

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