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Multiple Sclerosis and Dantrium

Dantrium® (dantrolene sodium) is a muscle relaxant prescribed to treat muscle spasticity caused by neurological conditions, such as a stroke, cerebral palsy, or multiple sclerosis. Dantrium is also approved for treating or preventing a potentially life-threatening condition called malignant hyperthermia.
Unlike other muscle relaxants, Dantrium works directly on the muscle. It is thought to work by interfering with calcium release from calcium storage sites in the muscles known as sarcoplasmic reticulum. The sarcoplasmic reticulum release calcium during muscle contractions. By interfering with calcium release, Dantrium causes the muscles to relax.
(To learn more about using this drug for conditions like multiple sclerosis, click Dantrium Uses. This full-length article describes this use of the medicine in more detail and also covers other uses, including some unapproved reasons that a healthcare provider may prescribe it.)
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