Multiple Sclerosis Home > Dantrium

Dantrium is a muscle relaxant prescribed to control muscle spasms caused by strokes, cerebral palsy, and other medical conditions. It is also approved to prevent or treat a serious reaction to anesthesia called malignant hyperthermia. This prescription drug comes as a capsule or injection. Side effects may include dizziness, fatigue, and weakness.

What Is Dantrium?

Dantrium® (dantrolene sodium) is a prescription medication approved to control muscle spasms and stiffness (spasticity) associated with certain medical conditions, such as spinal cord injury, stroke, cerebral palsy, or multiple sclerosis. It is also approved to prevent or treat a rare condition known as malignant hyperthermia, which is a severe reaction to general anesthesia that causes high fever and muscle rigidity.
(Click Dantrium Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medication?

Brand-name Dantrium is made by JHP Pharmaceuticals, LLC. There are also generic versions, which are made by various companies.

How Does Dantrium Work?

Dantrium belongs to a group of medicines known as muscle relaxants. However, unlike other muscle relaxants, Dantrium works directly on the muscle. It is thought to work by interfering with calcium release from calcium storage sites in the muscles known as sarcoplasmic reticulum. The sarcoplasmic reticulum release calcium during muscle contractions. By interfering with calcium release, Dantrium causes the muscles to relax.
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Last reviewed by: Kristi Monson, PharmD;
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