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More Details on Drug Interactions With Tizanidine

The following sections explain in detail the potentially negative interactions that can occur when tizanidine is combined with any of the drugs listed above.
Alcohol can increase the absorption of tizanidine, possibly increasing the levels of the medication in the blood. Combining alcohol with tizanidine can cause additive effects, such as increased drowsiness, confusion, memory loss, or difficulty breathing. It is best to avoid alcohol while taking this medicine.
Blood Pressure Medications
Tizanidine can lower blood pressure, which could be a problem for people already taking high blood pressure medications. If you are taking any medication for high blood pressure, check with your healthcare provider before taking tizanidine.
CYP1A2 Inhibitors
The liver metabolizes (breaks down) tizanidine using an enzyme known as CYP1A2. Other medications can slow down this enzyme, thereby delaying the breakdown of tizanidine. This could lead to high medication levels in the blood and may increase the risk of tizanidine side effects.
Check with your healthcare provider before taking tizanidine with any CYP1A2 inhibitor medication. Some strong CYP1A2 inhibitors, such as ciprofloxacin and fluvoxamine, should never be combined with tizanidine.

Final Thoughts

It is possible that not all tizanidine drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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