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Novantrone Overdose

Using too much Novantrone (mitoxantrone) may cause infections, extremely low blood cell counts, and even death. However, an overdose on this medicine is not likely to occur, as your healthcare provider will administer each dose. If the amount is miscalculated or if too much is given, treatment options will consist of providing supportive care to treat any symptoms that occur.


Can You Use Too Much Novantrone?

Novantrone® (mitoxantrone) is a prescription medication that belongs to a general class of drugs known as antineoplastics. Antineoplastics are used in the treatment of cancer. Novantrone is also approved to treat multiple sclerosis.
As with most medicines, it is possible to overdose on Novantrone. The specific effects of an overdose would likely vary, however, depending on a number of factors, including the Novantrone dosage and whether it was combined with any other medications or substances.

Effects of an Overdose

Because this medication is normally given by a trained healthcare provider, an intentional overdose is unlikely to occur. However, there have been reported cases of accidental overdoses with Novantrone. Based on these reports, possible symptoms may include:
  • Extremely low white blood cell counts
  • Infections
  • Death.

Treatment Options for a Novantrone Overdose

There is no antidote for a Novantrone overdose. In addition, dialysis is not expected to be useful for removing this medicine from the bloodstream.
The treatment for an overdose of Novantrone will mostly involve supportive care, which consists of treating any symptoms that occur as a result of the overdose. Supportive treatment may include:
  • Close monitoring of blood cell counts
  • Antibiotics if an infection occurs
  • A medication known as granulocyte colony-stimulating factor (G-CSF), such as filgrastim (Neupogen®), to stimulate the bone marrow to make more white blood cells.
Seek immediate medical attention if you or someone else may have received too much of this medication.
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Novantrone Medication Information

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