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Novantrone Uses

Healthcare providers may prescribe Novantrone for use in the treatment of certain types of multiple sclerosis, hormone-refractory prostate cancer, and acute nonlymphocytic leukemia. This medicine works by damaging DNA, preventing certain cells from dividing and multiplying. There are also some off-label unapproved uses, such as treating breast cancer, non-Hodgkin's lymphoma, and certain types of leukemia in children.


What Is Novantrone Used For?

Novantrone® (mitoxantrone) is a prescription antineoplastic (anticancer) medication. It is approved for use alone or in combination with other medicines to treat the following conditions:

Using Novantrone for the Treatment of Multiple Sclerosis

Multiple sclerosis is a chronic disease that affects the central nervous system (brain and spinal cord). In MS, the body's immune system attacks myelin, the protective covering that insulates nerve cell fibers. In addition, the nerves themselves may become damaged.
Myelin facilitates the smooth, high-speed transmission of electrochemical messages between the brain, the spinal cord, and the rest of the body. When myelin and nerves are damaged, the transmission of messages is slowed or blocked, leading to the primary symptoms of the disease. The actual symptoms of MS can vary from person to person, depending on the extent and location of the nerve and myelin damage.
(Click Symptoms of Multiple Sclerosis to learn more.)
MS can generally be categorized into one of four main types, based on how the disease progresses. These four types include:
  • Relapsing-remitting, which is characterized by periods of relapse (when symptoms are worse) alternating with periods of remission (periods of recovery)
  • Primary-progressive, which is characterized by a gradual decline in function, with no distinct periods of remission
  • Secondary-progressive, which begins with a relapsing-remitting course followed later by a primary-progressive course
  • Progressive-relapsing, in which the disease becomes progressively worse, with acute attacks flaring up along the way.
(Click Types of Multiple Sclerosis to learn more about these four patterns of disease progression.)
Novantrone is approved to reduce disability and the frequency of relapses in people with secondary-progressive, progressive-relapsing, or relapsing-remitting multiple sclerosis. It is not approved for use in people with primary-progressive forms of MS.
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Novantrone Medication Information

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