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Rebif Dosage

The usual Rebif dosage is 22 or 44 mcg, injected three times a week. You should start with a low dose and slowly work up to the full dosage over a four-week period. Your healthcare provider will explain how to increase your Rebif dosage. He or she may also recommend that you take an over-the-counter pain reliever to prevent flu-like symptoms common with the drug.

Rebif Dosage: An Introduction

The dose of Rebif® (interferon beta-1a) that your healthcare provider recommends will vary, depending on a number of factors, including:
  • How you respond to Rebif
  • Other medical conditions you may have
  • Other medications you may be currently taking.
As always, do not adjust your dose unless your healthcare provider specifically instructs you to do so.

Rebif Dosage for Multiple Sclerosis

The recommended dose of Rebif for treating multiple sclerosis (MS) is 22 mcg or 44 mcg, injected three times a week. Both doses are safe and effective. You will likely start at a lower dose and slowly work up to the full dose over a four-week period. Your healthcare provider will instruct you on how to increase your dose.
Your healthcare provider may recommend that you take a non-prescription pain reliever, such as Tylenol® (acetaminophen) before, at the same time, or after each Rebif injection. This can help prevent some of the flu-like symptoms (such as fever, chills, and muscle aches) that are common with Rebif.
Rebif comes in two different types of syringes -- prefilled syringes (which are injected manually) or auto-injectors. Because the entire dose must be given with the auto-injectors (there is no possibility for injecting half a dose, as can be done with the prefilled syringes), the titration up to 22 mcg must be done with prefilled syringes only.
Once you’ve reached the 22-mcg dose, you can use either the prefilled syringes or the auto-injectors. For the titration up to the 44-mcg dose, either the prefilled syringes or the auto-injectors may be used. 
Know the Signs - Concussion Safety

Rebif Injection for MS

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