Rebif Drug Interactions

Chemotherapy, zidovudine, and theophylline products can interact negatively with Rebif. Drug interactions could occur that may increase the levels of medicine in your blood or decrease the level of certain types of blood cells. To reduce your risk of developing Rebif drug interactions, tell your healthcare provider about all other medications you are taking, including non-prescription ones.

Rebif Injection for MS

An Introduction to Rebif Drug Interactions

Rebif^® (interferon beta-1a) can potentially interact with a few other medications. Some of the medicines that may lead to Rebif drug interactions include:

Chemotherapy treatments
Theophylline products (Elixophyllin^®, Theo-24^®, TheoCap™, Theochron^®, Uniphyl^®)
Zidovudine (Retrovir^®) or combination medications that contain zidovudine (Combivir^®, Trizivir^®).

Rebif Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Rebif is combined with any of the drugs listed above.

Chemotherapy Medications

Both chemotherapy medications and Rebif can decrease the level of certain blood cells. Therefore, taking them together increases the risk of such problems. Do not combine these medications without checking with your healthcare provider first.

Theophylline (Elizophyllin, Theo-24, TheoCap, Theochron, Uniphyl)

Interferons (such as Rebif) may increase the level of theophylline in your blood, possibly increasing the risk of side effects. Your healthcare provider may need to monitor your theophylline blood levels and adjust your dosage as necessary if you are taking both of these medications.

(Rebif Drug Interactions Continued: Page 2)