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Rebif Side Effects

Redness at the injection site, fatigue, and headache are some of the most commonly reported side effects of Rebif. Those that are potentially serious and that should be reported to a healthcare provider include unusual bleeding or bruising, depression, and seizures. However, it is important to know that in most cases, side effects of this drug are minor and usually do not require medical attention.

An Introduction to Rebif Side Effects

As with any medicine, side effects are possible with Rebif® (interferon beta-1a); however, not everyone who takes the drug will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can be treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects of this drug. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects of Rebif

Rebif has been studied thoroughly in clinical trials. In these studies, the side effects that occur in a group of people taking the drug are documented and compared to side effects that occur in another group of people not taking the medicine. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
In these studies, the most common Rebif side effects included:
  • Skin reactions at the injection site (such as redness or pain) -- in up to 92 percent of people
  • Headaches -- up to 70 percent
  • Flu-like symptoms (such as fever or chills) -- up to 59 percent
  • Fatigue -- up to 41 percent
  • Muscle pain -- up to 25 percent
  • Back pain -- up to 25 percent.
Other common side effects (occurring in 2 to 20 percent of people) included:
  • Abdominal pain (stomach pain)
  • A general ill feeling (malaise)
  • Coordination problems
  • Dry mouth
  • Bone pain
  • Drowsiness
  • Frequent urination
  • Bladder control problems
  • Vision problems.
Know the Signs - Concussion Safety

Rebif Injection for MS

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