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How Rebif Works and Pediatric/Off-Label Indications

How Does Rebif Work?

Even though Rebif is made using Chinese hamster ovary cells, it is made up of exactly the same amino acids as human interferon. Interferons are naturally occurring proteins or glycoproteins (proteins attached to carbohydrates). In humans, interferons are produced by cells in response to certain situations, such as viral infections, and often play a key role in the immune system.
At this time, it is not fully understood how Rebif works to treat MS. Although the exact causes of MS are not known, it is often considered an autoimmune disease in which the immune system attacks and destroys the protective coating around nerve fibers. Rebif may work by limiting this immune system response, decreasing the damage to the nerves.
Because Rebif is a glycoprotein (made up of proteins and carbohydrates), it would be broken down and destroyed by the digestive system if taken by mouth. Thus, the medication must be injected to bypass the digestive tract.

Rebif Uses in Children and Teens

Rebif is not approved for individuals under 18 years old. Talk to your healthcare provider about the benefits and risks of using the drug in children or teens.

Off-Label Rebif Uses

On occasion, your healthcare provider may recommend Rebif for something other than treating relapsing MS. This is called an "off-label" use. At this time, using the drug to treat other types of MS is considered an off-label Rebif use.
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Rebif Injection for MS

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