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How Often Do Problems Occur With Tizanidine?

Common Side Effects

Tizanidine has been studied extensively in clinical trials. In these studies, side effects occurring in the group of people taking tizanidine were documented and compared to those that occurred in a similar group of people taking a placebo (a "sugar pill" with no active ingredients).
Based on these studies, the most common side effects of tizanidine tablets included:
  • Drowsiness -- in up to 92 percent of people
  • Dry mouth -- up to 88 percent (see Zanaflex and Dry Mouth)
  • Weakness, fatigue, or tiredness -- up to 78 percent
  • Dizziness -- up to 45 percent
  • Low blood pressure (hypotension) -- up to 33 percent
  • A slow heart rate (bradycardia) -- up to 10 percent
  • Urinary tract infection (UTI), such as a bladder infection -- up to 10 percent.
Other common reactions (occurring in 3 to 6 percent of people) included:
  • Infection
  • Constipation
  • Increased liver enzymes (found using a blood test)
  • Vomiting
  • Speech problems
  • Blurred vision
  • Frequent urination
  • Flu symptoms (such as a fever and chills)
  • Nervousness
  • Sore throat
  • Runny or stuffy nose
  • Abnormal, involuntary muscle movements.

Final Thoughts

You may experience some or none of the tizanidine side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine that you have never tried.
Therefore, make sure to let your healthcare provider know if you develop any adverse reactions while taking this product. Also, let your healthcare provider know if you develop something that "just does not seem right." While it may not be a side effect of tizanidine, your healthcare provider will be able to diagnose and treat the problem.
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