If you have Crohn's disease or multiple sclerosis and other treatments have failed, your healthcare provider may start you on Tysabri. The standard dosage of this medication is usually 300 mg administered intravenously (by IV) every four weeks. It will take about one hour to receive each dosage. Let your healthcare provider know if you develop potentially serious reactions, such as dizziness, itching, or nausea.
An Introduction to Dosing With TysabriThere is only one standard dosage of Tysabri® (natalizumab), regardless of your age or weight. As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
Tysabri Dosage for Multiple SclerosisThe standard dosage of Tysabri for treating multiple sclerosis is 300 mg, once every four weeks. The dose is given slowly into a vein (called an IV infusion) at a rate of about 5 mg per minute. At this rate, it takes approximately one hour to administer the entire dose.
Tysabri Dosage for Crohn's DiseaseThe standard dosage of Tysabri for treating Crohn's disease is 300 mg, once every four weeks. The dose is given slowly into a vein at a rate of about 5 mg per minute. At this rate, it takes approximately one hour to administer the entire dose.
Treatment should be stopped if a benefit is not seen within 12 weeks. Treatment should also be stopped if corticosteroids (such as prednisone) cannot be discontinued within six months of starting Tysabri, or if corticosteroids are needed to help control Crohn's disease symptoms for more than three months in a one-year period.
Regardless of whether you receive Tysabri for multiple sclerosis or Crohn's disease, you will be carefully monitored while receiving your dose and for at least one hour after it is given. This is because some people may experience a potentially serious reaction to the Tysabri infusion. Let your healthcare provider know if you experience any symptoms of such a reaction, which may include:
- Nausea and vomiting
- Sudden redness and warmth of the face, neck, and chest (flushing)
- Shortness of breath or wheezing
- Low blood pressure (hypotension), which could cause dizziness or fainting.